Questions people askOther medicines
The short answer
Shots that lower LDL by about 50 to 60% on top of a statin. They're usually for very high risk, familial hypercholesterolemia, or when statins don't suit you.
Repatha and Praluent are shots every 2 or 4 weeks, Lerochol once a month, and Leqvio (a related medicine) twice a year at a clinic. Repatha and Praluent have trials showing fewer heart attacks and strokes.
Source: FOURIER, NEJM 2017; ODYSSEY OUTCOMES, NEJM 2018; ORION-10/11, NEJM 2020.
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